Beilstein J. Org. Chem.2014,10, 1213–1219, doi:10.3762/bjoc.10.119
processes.
Keywords: fluorinated building blocks; fluoroarylaceticacid; fluoromalonate; fluorooxindole; organo-fluorine; selective fluorination; Introduction
Since 1954, when Fried and Sabo observed that the incorporation of a fluorine atom into a corticosteroid derivative led to valuable enhanced
PDF
Graphical Abstract
Scheme 1:
SNAr reaction of 2-fluoronitrobenzene (2a) with diethyl 2-fluoromalonate (1).